The effect of ketogenic diets on neurogenesis and apoptosis in the dentate gyrus of the male rat hippocampus

Abstract Ketogenic diets (KD) have become popular diet to lose weight. However, the effect of such on brain function has not yet been clarified. Thus, we aimed study effects KD neurogenesis and apoptosis in dentate gyrus by assessing expression Ki-67 Caspase-3. Rats ( n = 24) were divided into four groups: control (normal diet), ketogenic (KD), time-restricted (TRD), combination high-fat (CD) groups. The TRD CD groups was higher compared others P < 0.05), whereas no difference observed group. number Capase-3-positive cells decreased significantly group but decrease These results indicate that, although could be effective reducing body weight, possible adverse cannot ignored.